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Pain is good. It鈥檚 the body鈥檚 way to keep an animal from harming itself yeezy damen or repeating a dangerous mistake. But sometimes the debilitating sensation can ge nike dunk t in the way. So evolution has devised ways to tamp that response down under certain circumstances.Researchers at UC Santa Barbara identified the pathway in fruit flies that reduces the sensation of pain from heat. Remarkably, just a single neuron on each side of the animal鈥檚 brain controls the response. What鈥檚 more, the molecule responsible for suppressing this sensation in adult flies has the opposite role in fly larvae. The surprising r nike airforce esults appear inCurrent BiologyThe brain of a fruit fly has about a million-fold fewer neurons than our own. 鈥淵et we didn鈥檛 anticipate that a single pair of neurons would have such an important role in pain suppression,鈥?said senior authorCraig Montell, Duggan professor and distinguished professor of molecular, cellular and developmental biology.鈥淲e call them 鈥楨pione,鈥?or Epi neurons, for the Greek go KARACHI:Engro Corporation has posted a profit of Rs2.5 billion in the second quarter ended June 30, 2016, down 43% compared to Rs4.4 billion in the same period of previous year, according to a company notice sent to the Pakistan Stock Exchange (PSX) on Thursday.Earnings per share nb 993 (EPS) came down to Rs3.49 in Apr-Jun 2016 from Rs8.34 in the corresponding quarter of previous year.The quarterly result took total profits of the company in the first six months (Jan-Jun) of 2016 to Rs6.9 billion (EPS Rs10.54), down 28% year-on-year from Rs9.6 billion ( ugg mini EPS Rs15.28).The company also announced an interim cash dividend of Rs7 per share, which took payout in the first half of the calendar year to Rs12 per share.Topline Securities commented in its report that the result was below street consensus, which hit it ugg hausschuhe s share price that closed at Rs325.75, down 1.82%, on the PSX. The benchmark KSE 100-share Index closed at 39,771, down 286 points or 0.71%.Engro鈥檚 fertiliser business (EFERT) remained a lagg

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The findings are being published today in the scientific journal Nature Physics.In living cells, DNA-binding proteins regulate the activity of va <a href=https://www.nike-dunks.de>nike dunks high rious genes so that different cells carry out the right tasks at the right time. For this to work, the DNA-binding proteins need to find the right DNA site sufficiently quickly. The research team behind the new study has previously succeeded in determining that it takes only a few minutes for an individual protein molecule to look through the millions o yeezy schuh f nearly identical binding alternatives and find the right place to bind. This is nevertheless slower than what is predicted by the established theoretical model for how DNA-binding proteins find their way to the proper place by alternating b yeezy etween diffusing in the cell cytoplasm and along DNA strands."By also taking into consideration the fact that there are many obstacles in the way when proteins are to diffuse along DNA strands, we can now calculate more exactly how long it takes them to find A day after Pak Sarzameen Party (PSP)鈥檚 caravan received a hostile reception in Mirpurkhas, party leader Mustafa Kamal lashed out at Muttahida Qaumi Movement (MQM) chief over his alleged involvement in t new balance grise he attack which injured at least 10.鈥淚f we had not challenged this 鈥楶haraoh,鈥?we would not have been blessed by the Almighty speak the truth],鈥?the former Karachi mayor said in a veiled reference to the MQM supremo while addressing a presser in Hyderabad on Friday.Mustafa K newbalance amal鈥檚 caravan attacked in Mirpurkhas鈥淗e Hussain] is not more than a clown,鈥?Kamal said as he urged media not to give the MQM chief much importance. 鈥淗e is a coward who hurls abuses one day and asks for forgiveness the next day.鈥滽amal reiterated his claim that his party had remained successful in attracting the masses and garnering their support 鈥渨hich is why we are being attacked.鈥濃€淲e are not afraid of death, we will welcome death the day it is destined for us. We <a href=https://www.nbbalance.fr>new balance bleu have recognised Allah as the one and only

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A new publication from a Montana State University scientist deepens existing knowledge of an ancient life-form and how it continues unique ecological processes today.The paper, titled 鈥淢ethanogens acquire and bioaccumulate nickel during reductive dissolution of nickelian pyrite,鈥?was published today in Applied and Environmental Microbiology, a journal from the American Society for Microbiology. The authors of the publication are professorEric Boyd, former postdoctoral researcher Rachel Spietz and current postdoctoral researcher Devon Payne. Boyd鈥檚 lab is housed in theDepartment of Microbiology and Cell Biologyin MSU鈥檚College of Agriculture.A key element of Boyd鈥檚 res adidas yeezy earch has been the exploration of microorganisms called methanogens, which are ancient life-forms that still dunk nike high exist today. Methanogens are unique because they don鈥檛 use sunlight to power their metabolisms like most organisms do and are poisoned by oxygen. Instead, their metabolism u yeezy 350 ses chemicals from their environment, often In recent days these columns have reflected our frustration at the seeming impossibility of resolving the problems that beset our relationship with India, and their interconnectedness to a range of other regional issues, one of which is a perception that Pakistan has become isolated. It is not difficult to see why parts of the international community see stanley cup Pakistan as isolated and out of step; and it appears that the government has finally woken up to this uncomfortable reality. A three-day session which brought together our envoys to nine countries with which we have key relationships has just concluded, and the prime minister addressed the final plenary session. A platter of critical challenges was laid before the ambassadors, principal am new balance nere ong which were peace with adidas campus the neighbours, the defeat of extremism and terrorism on the home front, support for the Kashmir independence movement, the China-Pakistan Economic Corridor and lastly and perhaps most urgently the promotion of a positive ima

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People with Parkinson鈥檚 disea nike dunk se and their doctors confront many unknowns, including the answer to exactly how deep brain stimulation (DBS) relieves some of the motor symptoms patients experience. In a new study, scientists at Boston University and The Picower Institute for Learning and Memory at MIT present a detailed model explaining the underlying circuit dynamics, providing an explanation that, if experimentally confirmed, could improve the therapy further.Among the things that are known about Parkinson鈥檚 disease is that a deficit of the neuromodulator dopamine is associated with abnormally high beta-frequency rhythms (brain waves at a adidas yeezy frequency of about 20 Hz). DBS, involving the delivery of high-frequency electrical stimulation to a region called the subthalamic nucleus (STN), apparently suppresses these elevated beta r adidas yeezys hythms, restoring a healthier balance with other rhythm frequencies and better movement control.The new biophysically-based computational model described in theProc KARACHI:The much needed adidas samba og and long awaited project to provide the city with additional water, commonly known as the K-IV project, has hit a snag, as owners of 15 acres of land in Gadap Town, which has allegedly been acquired for the project without compensation, have challenged the project in the Sindh High Court (SHC).A two-judge bench, headed by Justice Munib Akhtar, has also issued notices to the provincial chief secretary, managing director of the Karachi Water and Sewerage Board (KWSB) and director-general of th new balance donna e Frontier Works Organisation (FWO) to file the ugg boots ir comments by August 9.The bench passed these directives on Thursday while hearing a petition challenging the acquisition of 15 acres of land for the project allegedly without payment of compensation to the land owners.Illegal constructions in Sindh irk apex courtThe judges ordered the government and K-IV project officials to act in accordance with the law till the next date of the hearing and before beginning work or stepping f

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Neurons in the brain鈥檚 master clock that adjust their activity in response to light have a key role in the resetting of an animal鈥檚 daily cycle, finds a study of male and female mice pub new balance sneaker lished in JNeurosci. These cells may be re yeezy 500 sponsible for circadian rhythm disruptions stemming from exposure to artificial light at night.By demonstrating in mice that suprachiasmatic nucleus (SCN) neurons expressing the neuropeptide vasoactive intestinal peptide (VIP) exhibit a regular cycle in their activity levels that is disrupted under conditions of constant light, Erik Herzog and colleagues resolve long- dunks nike store standing questions about how the SCN synchronizes the body鈥檚 daily rhythms to environmental light. Blocking the activity of these neurons reduced the severity of shifts in daily rhythms. These findings suggest a potential mechanism by which the modern advent of light at night may have led to an increased prevalence of sleep disorders.This article has been republished frommaterialsprovided bySfN. Not ISLAMABAD:For many women in Pakistan, the simple act of leaving the house can be uncomfortable, even intimidating -- the probing gaze of the opposite sex is never far aw adidas samba adidas ay.Fed-up with the constant unwanted attention, broadcaster Anila Ansari decided to bring the touchy subjects of harassment to the airwaves, by launching an "anti-ogling campaign" on her national radio show.The idea -- unprecedented in this conservative Muslim country where misogyny is ofte boots kaufen n legitimised by hardline clerics -- came to her at the start of the year when she returned to he adidas samba og r country after living for two decades in Great Britain.Apathy towards sexual violenceEverywhere she went in public spaces, she felt endlessly intimidated by the male gaze -- and found she was far from alone."I went to different offices, restaurants: everywhere I went I could see these eyes following me," she told AFP from the Radio99 office located in the centre of Islamabad."So I came to my office and started asking my female colleagues

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Scientists hoping to get a glimpse of molecules that control brain activity have devised a new probe that allows them to image these molecules without using any chemical or radioactive labels.Currently the go <a href=https://www.adidas-yeezy.it>yeezy slides ld standard approach to imaging molecules in the brain is to tag them with radioactive probes. However, these probes offer low resolution and they can鈥檛 easily be used to watch dynamic events, says Alan Jasanoff, an MIT professor of biological engineering and brain and cognitive sciences.Jasanoff and his colleagues have developed new sensors consisting of proteins designed to detect a particular target, which causes them to dilate blood vessels in the immediate area. This produces a change in blood f yeezy slide low that can be i nike dunk high maged with magnetic resonance imaging (MRI) or other imaging techniques.鈥淭his is an idea that enables us to detect molecules that are in the brain at biologically low levels, and to do that with these imaging agents or contrast agents that can ultimately be used in huma ISLAMABAD:A petitioner has approached the Islamabad High Court against the 鈥渋llegal鈥?parking of vehicles on footpaths and other public spaces by owners new balance 996 of car showrooms in the capital.The petitioner, through his cou adidas campus bianche nsel Yasir Mehmood Chaudhary, has filed a petition and made the chairman of the Capital Development Authori adidas samba bianche ty and Islamabad Metropolitan Corporation Mayor Shiekh Anser Aziz, Inspector General of Police and Deputy Commissioner of the Islamabad Capital Territory as respondents.Removing encroachment: RMC forms codeThe counsel said that owners of the car showrooms park their vehicles over footpaths and on spaces meant for the public to park their cars. As a result, it compels petitioner and other pedestrians to walk on the main road 鈥渨hich is risky because of speedy traffic.鈥滳haudhary said that owners of car showrooms had parked their vehicles on the footpaths in Sector G-8, G-9 and F-10, making it difficult for pedestrians to walk on the footpaths.Even t