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Gapp Gene Editing in the Third Domain of Life
Alnylam Pharmaceuticals, Inc. has announced that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration (FDA) for ALN-VSP, an RNAi therapeutic for the treatment of liver cancers, including hepatocellular carcinoma and other solid tu dunks mors with liver involve newbalance schuhe ment.ALN-VSP contains two small interfering RNAs (siRNAs), the molecules that mediate RNAi, formulated in a lipid nanoparticle developed by Tekmira Pharmaceuticals Corporation.ALN-VSP is designed to target two genes critical in the growth and development of cancer: kinesin spindle protein, or KSP, required for tumor proliferation; and vascular en air force 1 damen dothelial growth factor, or VEGF, required for tumor growth. Pre-clinical data in mouse tumor model studies have demonstrated robust efficacy of ALN-VSP, including suppression of these targeted genes, demonstration of an RNAi mechanism of action, tumor reduction, and extension of survival.鈥淎LN-VSP represents Alnylam鈥檚 first IND for a systemically ISLAMABAD:A day after formally taking charge of Pakistan Army, General Qam adidas campus blu ar Javed Bajwa on Wednesday outlined his priorities saying the defence and security of Pakistan against external and internal threats will remain his ultimate objective as chief of army staff.In a major policy statement, the newly-app adidas campus homme ointed army chief also emphasised that the war against terrorism would continue with a 鈥榝ocused approach鈥?and that it would be taken to its logical conclusion.On his first visit to field formations after taking over command of Pakistan Army, Gen Qamar visited the Corps Headquarters Peshawar and North Waziristan, said Inter-Services Public Relations (ISPR) adidas campus pink in a statement giving the first insight into the new army chief鈥檚 take on a host of internal and external security challenges.Gen Qamar formally took charge of the army at a colourful ceremony held at the Hockey Stadium in Rawalpindi on Tuesday. He assumed the charge of arguably the most powerful and challenging job at a time when P

Xuoo US students; rape allegation against Italian police has ;some basis;, minister says
Marina Biotech, Inc., has announced the initiation of patient dosing in the Dose Escalation Phase of its START-FAP (Safety and Tolerability of An RNAi Therapeutic in Familial Adenomatous Polyposis) clinical trial with CEQ508.Marina Biotech's Phase 1b/2a trial is an open-label, escalating-dose study of single daily d <a href=https://www.nike-dunk.es>dunk cacao oses of CEQ508 and will be conducted as a single center study in Boston, Massachusetts.The first cohort comprised of three patients will be administered the starting dose of 1x10(8) colony forming units (cfu)/day. The study is primar nb sneakers 574 ily designed to evaluate the safety and tolerability of CEQ508 in patients with Familial Adenomatous Polyposis (FAP) after 28 days of daily, oral dosing.The trial is also intended to provide data on beta-ca converse all star tenin biomarker changes pre- and post-treatment and pharmacokinetic data related to the gastrointestinal coverage of CEQ508. The Dose Escalation Phase consists of 12 patients in four dose escalating cohorts; two patients in the first dosing gro KARACHI:While the neighbourhood of Lyari earns most of its attention adidas samba sale through crimes and gang violence, this time new balance 480 it鈥檚 the construction work being carried out for Pakistan鈥檚 first-ever boxing ring for women that sheds the spotlight on the run-down聽locality. The name plate of the cl adidas samba negras ub hangs on the wall. PHOTO: AYESHA MIR/ EXPRESS

Tnnk Pakistan s biggest footballing event
Scien dunk femme tists have taken a promising step towards a new generation of accurate, affordable and portable devices to detect concussion, epilepsy and dementia.The international research team developed a laser-based diamond sensor that can measure magnetic fields up to 10 times more precisely than standard techniques. Their results are published in鈥疭cience Advances.Their innovation could help imp asics rove on existing magnetic-field sensing techniques for mapping brain activity to identify disorders. With sufficient funding and collaboration with industry, the team say they could develop a proof-of-concept device using their new sensor within 5 years. Concussion in sport has been in the spotlight recently with prominent athletes sharing their stories about the significant ramificati yeezy boost ons of head injuries sustained during their careers. Meanwhile, about 250,000 Australians live with epilepsy, while nearly 500,000 Australians have some form of dementia.The research is also relevant to a range of sector KARACHI:Foreign-based swimmers Lianna Swan and Haris Bandey will represent Pakistan at the Rio Olympics as wild card entrants after the International Swimming Federation (FINA) approved their names.The two swimmers are participating in the Olympics for the first time. In the last edition, Haris鈥檚 elder sister, Anum Bandey, represented Pakistan in the 400m individual medley, along with Israr Hussain taking part in the 100m freestyle event. However, both swimmers failed to qualify for the next round and finished last among 35 participants and 54th ou adidas campus blanche t of 56 respectively.First judoka from Pakistan: Shah confirms spot in OlympicsThis time around, the Rio-bound swimmers are foreign-based and have represented Pakistan in several championships, including the recently held South Asian Games where Lianna became nb the first Pakistani swimmer to win a gold medal in the e stanley-cup vent. Haris, on the other hand, failed to perform well.Pakistan Swimming Federation (PSF) Secretary Veena Masud revealed FINA sele

Idzs Study to Examine if Vitamin D Prevents Diabetes
Increased consumpt yeezy femme ion of flavanols - a group of molecules which occur naturally in fruit and vege nike dunk low tables - can increase your mental agility, according to new research at the University of Birmingham.A team in the University's School of Sport, Exercise and Rehabilitation Sciences found that people given a cocoa drink containing high levels of flavanols were able to complete certain cognitive tasks more efficiently than when drinking a non-flavanol enriched-drink.The study participants also underwent non-invasive brain imaging to measure blood oxygenation levels in the brain. Working with experts at the University of Illinois, the researchers showed that participants who had consumed the flavanol-rich drink produced a faster and greater increase in b nike air forces lood oxygenation levels in response to artificially elevated levels of CO2(hypercapnia).Flavanols, a sub-group of plant flavonoids, are present in cocoa, grapes, apples, tea, berries and other foods. They are known to have a beneficial effect Monica Riley, a聽700 kilogramme funnel-fed woman is on a record-breaking spree.Riley, who is paid by men to gain newbalance 550 more weight as she posts photo adidas campus damen s and videos of herself eating, is determined to become t nb 530 he fattest woman in the world, reports Fox News.聽"I聽have 20,000 online fans and they love to watch the funnel feeding 鈥?it鈥檚 a big hit," she said. PHOTO: DAILYMAIL

Eaix Pardew;s job as manager is safe, says Palace chairman
Detailed analysis of the fossilised skin of a newly discovered species of dinosaur has revealed that despite being the size of a tank and heavily protected with armour, it was still hunted by savage predators.Palaeobiologist and expert on fossil pigments Dr Jakob Vinther, from the University of Bristol's School of Earth Sciences worked with researchers from the Royal Tyrrell Museum of Palaeont dunk panda ology in Alberta, Canada to study the 18-foot long specimen鈥檚 exquisitely well-preserved form.Using chemical analysis of organic compounds in the horns and skin to infer the dinosaur's pigmentation pattern they found that the skin exhibited countershading, a common form of camouflage in which an animal鈥檚 underside is lighter than its back.This suggests that the nodosaur, named Borealopelta markmitchelli, faced dunk chaussure predation stress from other meat-eating dinosaurs.Dr Vinther said: "We found a lot of sulphur bearing organic compounds, which we ciabatte yeezy later could confirm was evidence for reddish brown colourati ISLAMABAD:A day after stanley kaufen the government sacked its information minister, Pervaiz Rashid, over a 鈥榩lanted news story鈥? the security czar said no technical data was available to establish who had 鈥榣 adidas samba herren eaked鈥?the story to a daily Dawn reporter, though he disclosed that 鈥榯wo or three persons鈥?were under the radar.鈥淧ervaiz Rashid has been relieved of his office because he failed to stop the story from publication. He should have asked the reporter, Cyril Almeida, that the story i new balance uomo s fabricated and he should not publish it,鈥?Chaudhry Nisar Ali Khan, the federal interior minister, told a news conference at the Punjab House on Sunday.Heads start rolling over 鈥榩lanted story鈥橬isar disclosed that the reporter had met Rashid at his office 鈥?and this meeting was documented. 鈥淚f Cyril Almeida didn鈥檛 listen, then Pervaiz Rashid must have spoken to Dawn鈥檚 editor and management. This is a 鈥榣apse鈥?on Rashid鈥檚 part,鈥?added Nisar, who supervised initial inquiry into the story published in Dawn on October 6.Rashid

Owla AI May Reduce Unnecessary Treatments for Breast Cancer Patients
Northwestern Medicine scientists have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration that is seen in disease <a href=https://www.nbbalance.de>nb s such as ALS, which affects voluntary muscle movement such as walking and talking. The discovery was so novel, the scientists needed to coin a new term to describe it: mitoautophagy, a collection of self-destructive mitochondria in diseased upper motor neurons of the brain that begin to nike air force1 disintegrate from within at a very early age. Upper motor neurons in the brain are responsible for initiating muscle movement and relaxation and are one of the first to break down in neurodegenerative diseases.The study will be published on November 7 in the journal Frontiers in Cellular Neuroscience.The phenomenon is observed mainly in one of the most common pathologies observed in neurodegenerative diseases, TDP-43 pathology, which is seen in more than 90% of ALS cases. When a pathology is present in t asics outlets he body, it indicates that s SAN FRANCISCO:US ride-share startup Lyft on Friday dedicated a new team focused on speeding up its effort to create a self-driving vehicle platform, which would be o nb 9060 pen to use by other companies.The San Francisco based company earlier this year announced what it billed as the world's first open self-driving platform, inviting car manufacturers and rival autonomous navigation systems to plug into the network."In the years ahead, we will continue to bring the world's leading automotive and technology companies onto this single platform to serve a nationwide passenger network," Lyft vice president of engineering and former Google executive Luc Vincent said in an online post.Lyft, Waymo adidas samba blancas ink self-driving car deal - NY Times"We aren't thinking of our self-driving division as a side project; it's core newbalance 530 to our business."Lyft is devoting an in-house division to self-driving technology, according to Vincent.The team will be based in a Silicon Valley facility called "Level 5 Engineering Center" an